"Quantitative assessment of the extent and severity of vascular disease"

Dr. Milan Sonka
Iowa Institute for Biomedical Imaging


The presentation will focus on two main aspects of quantitative assessment of the extent and severity of vascular diseases: 1) screening for vascular disease presence and risk factors, and 2) assessment of disease severity in the presence of established vascular disease and plaque.

The talk will first discuss quantitative image-based approaches to assessing wall thickness (intima-media thickness or IMT) in carotid arteries using ultrasound and assessment of endothelial function in brachial arteries via flow mediated dilatation (or FMD) using ultrasound imaging. Both of these approaches are considered the earliest screening tests for cardiovascular disease and have a clear predictive value for development of heart attack and stroke. Quantitative image analysis solution will be presented that has become a de-facto standard for vascular ultrasound research studies worldwide.

Additional focus will be given to quantitative coronary image analysis via fusion of intravascular ultrasound (IVUS) and angiography, coronary plaque analysis, and plaque progression prediction based on IVUS-derived virtual histology. A summary of quantitative characteristics of coronary plaque morphology and tissue characterization will be presented.

The talk will be accompanied by live demonstrations of the software tools developed for the above-referenced purposes.


Milan Sonka received his Ph.D. degree in 1983 from the Czech Technical University in Prague, Czech Republic. He is Professor and Chair of the Department of Electrical & Computer Engineering, Professor of Ophthalmology & Visual Sciences, and Radiation Oncology at the University of Iowa, Director of the Iowa Institute for Biomedical Imaging, IEEE Fellow, and AIMBE Fellow. His research interests include medical imaging and knowledge-based image analysis with emphasis on cardiovascular, pulmonary, orthopaedic, and ophthalmic image analysis. He is the first author of 3 editions of Image Processing, Analysis and Machine Vision book (1993, 1998, 2008) and co-authored or co-edited 18 books/proceedings. He has published more than 90 journal papers and over 340 other publications. He is Editor in Chief of the IEEE Transactions on Medical Imaging and member of the Editorial Board of the Medical Image Analysis journal. To bring results of his research work to clinical practice, he has co-founded two medical image analysis companies -- Medical Imaging Applications LLC, and VIDA Diagnostics Inc.