"Photoacoustic Imaging"

Dr. Liang Song
Research Center for Biophotonics
Institute of Biomedical and Health Engineering
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences


Photoacoustic imaging is a rapidly growing emerging biomedical imaging technology that may become a vital imaging tool for various preclinical and clinical applications, including early diagnosis of cancer, noninvasive sentinel lymph node mapping, and intravascular imaging of vulnerable plaques.

As a break-through hybrid imaging modality, photoacoustic imaging combines the advantages of optical absorption contrast and ultrasonic resolution, which enables functional and molecular imaging at depths well beyond the optical ballistic and quasi-ballistic regimes. For example, its high sensitivity to optical absorption allows imaging of important physiological parameters, such as the hemoglobin concentration and oxygen saturation, which closely correlate with angiogenesis and hypermetabolism—two hallmarks of cancer.

In this talk, the basic principles and various system constructions of photoacoustic imaging will be introduced; its representative preclinical and clinical applications in cancer and cardiovascular imaging will also be addressed.


Liang Song is an Associate Professor at the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. He received his Ph.D. degree in Biomedical Engineering from Washington University in St. Louis (with Professor Lihong Wang), his M.Phil. degree in Physics from the Chinese University of Hong Kong, and his B.Eng. degree in Electronic Engineering from Wuhan University.

At Washington University, he developed novel photoacoustic microscopy (PAM) capable of imaging optical absorption contrast in vivo with high ultrasonic resolution at large depth in scattering biological tissue. He invented section-illumination PAM and multi-focal optical-resolution PAM, which can potentially speed up the clinical translation of PAM technology for many applications, including early diagnosis of cancer and atherosclerosis, as well as functional imaging of vascular complications in diabetes.

He has authored and co-authored more than 20 peer-reviewed journal and conference articles, has one U.S. and one World Patent pending, and two invited book chapters forthcoming. He serves as reviewers for multiple international journals and is a member of IEEE, OSA, and SPIE.